Formulation Challenges With Poorly Soluble Actives — And How to Solve Them
Poorly soluble active ingredients can make dietary supplement formulation development difficult by limiting bioavailability, creating manufacturing challenges, and complicating stability—issues that require thoughtful formulation strategies to overcome. Many actives, from certain pain relievers to botanical extracts, show promise in the lab but underperform once swallowed because they fail to dissolve fully in the body. This […]
Granulated vs. Direct Blend Powders: Which Is Better for Sachets?
Powder that clumps, sticks, or separates during filling can derail production and compromise quality. The foundation of a reliable sachet product starts with one key decision: granulation or direct blend. Granulation converts fine powders into denser, flowable granules using wet or dry processes. Direct blend powders are mixed and filled without modification. Here is a […]
Challenges in Manufacturing Multi-Component Formulas With Uniform Potency
Getting multiple active ingredients to work together in one dose is no small task. Multi-component drug products, such as fixed-dose combinations, supplements, and therapies that include multiple APIs, offer clear advantages. However, as the number of active ingredients increases, so does the complexity of manufacturing. As each component is introduced, the challenge of achieving uniform […]
Powder Blending and Granulation: Process Optimization for Manufacturing
A drug is only as good as the process behind it, and even the most potent compound can fail without a solid foundation in powder processing. Before a tablet reaches a patient or passes quality control, it must be made from powders that flow, compress, and hold together consistently. That is why, in pharmaceutical manufacturing, […]
Choosing the Right Dosage Form: Capsules, Tablets, Softgels, Liquids, Bulk Powders, and More
Selecting the best dosage form for supplements or pharmaceuticals is an important technical step which directly affects everything from patient compliance, product stability, and manufacturing feasibility. The right format can improve absorption, match your brand’s identity, and make manufacturing easier. Vici Health Sciences Blog What is Oral Solid Dosage (OSD): A Comprehensive Guide to OSD […]
Why Is Powder Blend and Flow Important for Manufacturing?
The way powder flows and blends directly affects product quality, regulatory compliance, and overall manufacturing efficiency. Consistency. That is what every pharmaceutical product depends on, especially when working with powders. For small pharmaceutical companies, limited batch sizes and tighter budgets leave very little room for waste, inefficiency, or failed batches. Understanding and controlling powder blend […]
Benefits of Capsule Dosage Form: A Practical Guide for Small Pharma
Capsules offer distinct advantages that simplify development, shorten timelines, and improve patient experience. When speed, flexibility, and patient appeal matter, capsules deserve serious attention. Tablets may dominate the market, but they are not always the best fit, especially for pharmaceutical companies developing new products. Vici Health Sciences Blog What is Oral Solid Dosage (OSD): A […]
Analytical Methodology: Validation, Verification, or Qualification – Choosing the Right Approach
Validation, verification, and qualification are often used interchangeably in pharmaceutical testing, but each has their own distinct meanings and all serve different purposes. Getting the test right is just as important in pharmaceutical manufacturing as making the drug. If the analytical method you go with is flawed, every result that follows is questionable. Beyond those […]
Analytical Testing for Peptide Formulations
Peptides are commonly used to treat diabetes, obesity, and metabolic disorders. These days, they are also being explored for cancer therapy because they can target specific cells and pathways in the body. Many drugs, including GLP-1 receptor agonists like Semaglutide and Tirzepatide, are examples of peptide-based treatments that have really shown a lot of potential. With […]
What Is HPLC and Why Is It So Commonly Used for Pharmaceutical and Dietary Supplement QC Testing?
HPLC is an advanced sorting tool for QC testing; it allows manufacturers to verify the quality of their products with high precision. It also helps ensure that products comply with cGMP and meet the regulatory requirements set by agencies like the FDA. How Does HPLC Work? HPLC separates substances in a liquid sample based on […]