Formulation Challenges With Poorly Soluble Actives — And How to Solve Them
Poorly soluble active ingredients can make dietary supplement formulation development difficult by limiting bioavailability, creating manufacturing challenges, and complicating stability—issues that require thoughtful formulation strategies to overcome. Many actives, from certain pain relievers to botanical extracts, show promise in the lab but underperform once swallowed because they fail to dissolve fully in the body. This […]
Choosing the Right Dosage Form: Capsules, Tablets, Softgels, Liquids, Bulk Powders, and More
Selecting the best dosage form for supplements or pharmaceuticals is an important technical step which directly affects everything from patient compliance, product stability, and manufacturing feasibility. The right format can improve absorption, match your brand’s identity, and make manufacturing easier. Vici Health Sciences Blog What is Oral Solid Dosage (OSD): A Comprehensive Guide to OSD […]
Why Is Powder Blend and Flow Important for Manufacturing?
The way powder flows and blends directly affects product quality, regulatory compliance, and overall manufacturing efficiency. Consistency. That is what every pharmaceutical product depends on, especially when working with powders. For small pharmaceutical companies, limited batch sizes and tighter budgets leave very little room for waste, inefficiency, or failed batches. Understanding and controlling powder blend […]
Benefits of Capsule Dosage Form: A Practical Guide for Small Pharma
Capsules offer distinct advantages that simplify development, shorten timelines, and improve patient experience. When speed, flexibility, and patient appeal matter, capsules deserve serious attention. Tablets may dominate the market, but they are not always the best fit, especially for pharmaceutical companies developing new products. Vici Health Sciences Blog What is Oral Solid Dosage (OSD): A […]
SBIR Grants for Early-Stage Drug Development
Small Business Innovation Research (SBIR) grants for early-stage drug development offer start-up biopharma companies seed funding that helps turn their innovative drug therapy concepts into successful FDA drug development programs. Bringing a new drug to the market can be quite complex and expensive, especially for small pharmaceutical companies. That is where the SBIR and Small […]
Key Considerations in Suppository Formulation Development
Suppositories are solid forms of medicine that are designed to be inserted into bodily openings like the rectum, vagina, or urethra. Once inside the body, they melt or dissolve to release the active ingredients for absorption. When it comes to creating the perfect suppository, it isn’t just about mixing ingredients together; it’s also about achieving […]
Solid State Properties of Drugs
A thorough understanding of the solid state properties of drugs is vital for pharma companies that want to develop effective pharmaceuticals. These properties affect how stable, soluble, and bioavailable a drug will be. In essence, a good grasp of how active pharmaceutical ingredients (APIs) behave in their solid form is important for making effective drugs. […]
What is Formulation Development?
Pharmaceutical formulation development is the science of developing a dosage form that contains an active ingredient along with inactive ingredients that can be administered to a patient. Examples of dosage forms include oral tablets, oral capsules, oral solutions, oral suspensions, ophthalmic drops, topical semisolids such as creams and ointments, or injections. Why is formulation development […]
Orally Disintegrating Tablets (ODTs): A Quick Guide to Fast-Dissolving Medication
Orally disintegrating tablets (ODTs) are solid dosage forms that rapidly dissolve in the mouth without the need for water, typically within seconds to a minute. They are designed to improve patient compliance, especially for those with difficulty swallowing, by providing a convenient and easy-to-administer alternative to traditional tablets. In this article, we’ll explore what ODTs […]
What Is GLP-1: Understanding Its Role in Formulation Development
What is GLP-1, and why is it important in formulation development? Glucagon-like peptide-1, or GLP-1, is a hormone that helps regulate blood sugar, manage appetite, and support digestion. Certain medications, known as GLP-1 agonists, mimic these functions and are especially helpful for people with type 2 diabetes or obesity. How can pharmaceutical companies ensure they […]